Paul B. Jones

Education

B.S. 1993, Oklahoma State University (Richard A. Bunce)
Ph.D. 1998, Duke University (Ned A. Porter)
Postdoctoral Research Associate 1998-2000,
The Johns Hopkins University (Craig A. Townsend)

Research Description

I am interested in studying how photochemistry is used in nature and in developing photochemical methods to generate synthetically and medically significant products. Because most organisms depend directly on photochemical processes for their survival, photochemistry is essential to life on earth. The chemistry of photosynthesis and vision are the best examples of this, but many species have more subtle life processes (e.g. circadian rhythms) that rely on photochemistry. In nature, photochemical pathways are well regulated and, like most biochemical pathways, generate specific products. In the laboratory, however, photochemical reactions often yield a variety of products with little or no regio- or stereoselectivity. Specificity in photochemical reactions is achieved in biochemical systems by steric and electronic control of the chromophore and of the molecules with which the excited chromophore interacts. Using these systems as a model, I intend to study how photochemistry can be used to control biological systems and how structure and reaction conditions can be used to direct photochemical reaction pathways.

Publications

17.	Sarma, S.J.; Jones, P.B. “Photochemistry of 1,n-Dibenzyloxy-9,10-anthraquinones.”  J. Org. Chem. 2010,  75, 3806-3813.
16.	Elkazaz, S.; Jones, P.B. “Photochemical hydroxylation of 1-methyl-9,10-anthraquinones; synthesis of 9′-hydroxyaloesaponarin II.” J. Org. Chem., 2010, 75, 412-416.
15.	Brinson, R.G.; Sarma, S.; Elkazaz, S.; Jones, P.B. “Observation of Heavy Atom Effects in the Development of Water Soluble Caged 4-hydroxy-trans-2-nonenal.” Org. Biomol. Chem. 2008 6 4204-4211.
14.	Oates, R.P.; Jones, P.B. “Photosensitized Tetrahydropyran Transfer.” J. Org. Chem.2008, 73, 4743-4745.
13.	Oshige, E.S.; Jones, P.B.   “Photoactivated artificial metalloesterases.”    J. Photochem. Photobiol., A: Chem.  2007,  192,  142-151.
12.	Zuidema, D.R.; Jones, P.B. “Triplet Photosensitization in Cyercene A and Related Pyrones.” J. Photochem. Photobiol. B: Biology, 2006, 83, 137-145.
11.	Zuidema, D.R.; Miller, A.K.; Trauner, D.; Jones, P.B. “Photosensitized Conversion of 9,10-Deoxytridachione to Photodeoxytridachione.” Org. Lett. 2005, 7, 4959-4962.
10.	Harrison, B.; Czerw, R.; Konchady, M.S.; Pai, D.M.; Lopatka, M.W.*; Jones, P.B. “Ionic Liquids Incorporating Nanomaterials as Lubricants for Harsh Environments.” Proc. ASME Materials Division, 2005. 100, 405-410.
9.	Hubbard, S.C.; Jones, P.B. “Ionic-Liquid Soluble Photosensitizers.” Tetrahedron2005, 61, 7425-7430.
8.	Brinson, R.G.; Hubbard, S.C.; Zuidema, D.R.; Jones, P.B. “Two New Anthraquinone Photoreactions.” J. Photochem. Photobiol. A. Chemistry. 2005, 175, 118-128.
7.	Zuidema, D.R.; Jones, P.B. “Photochemical Relationships in Sacoglossan Polypropionates.” J. Nat. Prod. 2005, 68, 481-486.
6.	Brinson, R.G.; Jones, P.B. “Caged trans-4-hydroxy-2-nonenal.” Organic Letters2004, 6, 3767-3770.
5.	Glenn, A.G.; Jones, P.B. “ Thermal Stability of Ionic Liquid BMI(BF4) in the Presence of Nucleophiles.” Tetrahedron Lett. 2004, 45, 6967-6969.
4.	Brinson, R.G.; Jones, P.B. “ N-Allyl-1,3-oxazines via a Facile Keto-ene/cyclization Tandem Reaction.” Tetrahedron Lett. 2004, 45, 6155-6158.
3.	Reynolds, J.D.; Brinson, R.G.; Day, C.S.; Jones, P.B. “Highly Strained Dihydroanthraquinones: Oxidation vs. Elimination.” Tetrahedron Lett. 2004, 45, 2955-2959.
2.	Jones, P.B.; Reynolds, J.L.; Brinson, R.G.; Butke, R.A., “Amine Mediated Photoreduction of Aryl Ketones in N-Heterocyclic Ionic Liquids.” ACS Symposium Series: Ionic Liquids as Green Solvents: Progress and Prospects. 2003, 856, 370-380.
1.	Reynolds, J.L.; Erdner, K.R.; Jones, P.B. “Photoreduction of Benzophenones by Amines in Room Temperature Ionic Liquids.” Organic Letters 2002, 4, 917-919.
	PBJ Publications with Craig Townsend
1.	Jones, P.B.; Parrish, N.M.; Houston, T.A.; Stapon, A.; Bansal, N.P.; Dick, J.D.; Townsend, C.A. “A New Class of Anti-Tuberculosis Agents.” J. Med. Chem., 2000, 43, 3304-3314.
2.	Parrish, N.P.; Houston, T.A.; Jones, P.B.; Townsend, C.A.; Dick, J.D. “In-Vitro Activity of a Novel Anti-Mycobacterial Compound, N-Octane Sulfonyl Acetamide, and its Effects on Lipid and Mycolic Acid Synthesis.” Antimicrob. Agents Chem.,2001, 45, 1143-1150.
3.	Parrish N.M.; Ko C.G.; Dick J.D.; Jones P.B.; Ellingson J.L.E.  “Growth, Congo Red agar colony morphotypes and antibiotic susceptibility testing of Mycobacterium avium subspecies   paratuberculosis.”    Clin. Med. Res. 2004,  2,  107-14.
	PBJ Publications with Ned Porter
1.	Jones, P.B.; Pollastri, M.P.; Porter, N.A. “2-Benzoylbenzoic Acid: A Photolabile Mask for Alcohols and Thiols.” J. Org. Chem., 1996,61, 9455-9461.
2.	Arroyo, J.G.; Jones, P.B.; Porter, N.A.; Hatchell, D.L. “In-Vivo Photoactivation of Caged-Thrombin.” Thrombosis & Haemostasis, 1997, 78(2), 791-793.
3.	Jones, P.B.; Porter, N.A. “2-Aroyl Benzoyl Serine Proteases: Photoreversible Inhibition or Photoaffinity Labeling?” J. Am. Chem. Soc. , 1999, 121, 2753-2761.
	PBJ Publications with Richard Bunce
1.	Bunce, R.A.; Peeples, C.J.; Jones, P.B. “Tandem S N2-Michael Reactions for the Preparation of Simple 5-Membered and 6-Membered Ring Nitrogen and Sulfur Heterocycles.” J. Org. Chem., 1992, 57, 1727-1733.
2.	Bunce, R.A.; Dowdy, E.D.; Jones, P.B.; Holt, E.M. “Functionalized Carbocycles by Tandem Dealkoxycarboxylation-Michael Addition Reactions.” J. Org. Chem., 1993, 58, 7143-7148.
3.	Bunce, R.A.; Dowdy, E.D.; Childress, S.; Jones, P.B. “2,2,3-Trisubstituted Tetrahydrofurans and 2H-Tetrahydrofurans by Tandem Demethoxycarbonylation-Michael Addition Reactions.” J. Org. Chem., 1998, 63, 144-151.