Ph.D., 2014, University of Wisconsin–Madison (Ronald T. Raines)
Postdoctorate, 2014–2017, The Scripps Research Institute (Dale L. Boger)
The Lukesh lab uses synthetic organic chemistry in an effort to generate novel redox-active molecules with interesting biological properties. With a broad interest in molecular design and its application to biology and medicine, we are actively pursuing the following areas of research:
Chemical Biology: The design and synthesis of new investigative tools for probing the chemical biology of reactive sulfur and selenium species within a biological setting.
Medicinal Chemistry: The design and synthesis of novel selenium-containing scaffolds with useful redox properties and therapeutic applications.
Synthetic Methodology Development: New synthetic methods involving organoselenium reagents and catalysts for accessing privileged heterocyclic scaffolds via key C–C bond forming reactions.
Students participating in this research are exposed to a wide variety of topics and techniques at the ever-widening interface of chemistry and biology.
“An ROS-Responsive Donor That Self-Reports Its H2S Delivery by Forming a Benzoxazole-Based Fluorophore,” Hu, Q.; Zhu, C.; Hankins, R. A.; Murmello, A. R.; Marrs, G.; Lukesh, J. C., III. J. Am. Chem. Soc. 2023, 145, 25486–25494. https://doi.org/10.1021/jacs.3c10446
“Enol-Mediated Delivery of Hydrogen Selenide from 𝛾-Keto Selenides: Mechanistic Insight and Evaluation,” Hankins, R. A.; Carter, M. E.; Zhu, C.; Chen, C.; Lukesh, J. C., III. Chem. Sci. 2022, 13, 13094–13099. https://doi.org/10.1039/D2SC03533B
“Intramolecular Thiol- and Selenol-Assisted Delivery of Hydrogen Sulfide,” Hu, Q.; Suarez, S. I.; Hankins, R. A.; Lukesh, J. C., III. Angew. Chem. Int. Ed. 2022, 61, e202210754. https://doi.org/10.1002/anie.202210754
“Arylselenyl Radical-Mediated Cyclization of N-(2-alkynyl)anilines: Access to 3-Selenylquinolines,” Zhu, C.; Nurko, M.; Day, C. S.; Lukesh, J. C., III. J. Org. Chem. 2022, 87, 8390–8395. https://doi.org/10.1021/acs.joc.2c00282
“Mitigating Doxorubicin-Induced Cardiotoxicity with an H2O2-Activated, H2S-Donating Hybrid Prodrug,” Hu, Q.; Yammani, R. D.; Brown-Harding, H.; Soto-Pantoja, D. L.; Poole, L. B.; Lukesh, J. C., III. Redox Biol. 2022, 53, 102338–102346. https://doi.org/10.1016/j.redox.2022.102338
“An Innovative Hydrogen Peroxide-Sensing Scaffold and Insight Towards its Potential as an ROS-Activated Persulfide Donor,” Hankins, R. A.; Suarez, S. I.; Kalk, M. A.; Green, N. M.; Harty, M. N.; Lukesh, J. C., III. Angew. Chem. Int. Ed. 2020, 59, 22238-22245. https://doi.org/10.1002/anie.202010530
INVITED COVER ARTICLE: “Selenosulfides Tethered to gem-Dimethyl Esters: A Robust and Highly Versatile Framework for H2S Probe Development,” Suarez, I. S.; Ambrose, R.; Kalk, M. A.; Lukesh, J. C., III. Chem. Eur. J. 2019, 25, 15736–15740. https://doi.org/10.1002/chem.201904133
Awards and Accomplishments
- F. M. Kirby Family Faculty Fellowship (2022–2025)
- NSF CAREER Award (2022–2027)