Jes Bolduc

Education

B.S. in Chemistry with Honors, Concord University 2007-2011

Ph.D. in Biochemistry, Wake Forest University 2011-2016 (Lowther Lab)

Post-doctoral Research Associate, UNC Chapel Hill 2016-2018 (Loeser Lab)

Post-doctoral Research Fellow, Vrije Universiteit Brussels 2018-2021 (Messens Lab)

Research Description

My previous research focused on structural determinants of recognition involved in redox-signaling
protein-protein interactions, or put another way: proteins have many binding partners. How do they
know which one to interact with given any particular cellular environment to ensure the desired cellular
outcome? More specifically, I worked on co-crystallizing peroxiredoxins with different binding partners,
characterizing their binding requisites, as well as elucidating downstream signaling effects when
peroxiredoxins were oxidized or overoxidized.

As an Assistant Teaching Professor, I am interested in studying how embodied learning theories and
Montessori-inspired practices can be applied in chemical education to improve student conceptual
understanding, scientific interest, self-motivation, and creativity.

Publications

Vo TN., Pueyo JM., Wahni K., Ezerina D., Bolduc JA., Messens J. PRDX1 Interacts with ASK1 Upon H2O2
Induction and Independently of a Scaffolding Protein. Antioxidants. June 2021; 10(7), 1060.

Bolduc JA., Koruza K., Luo T., Pueyo JM., Vo TN., Ezerina D., Messens J. Peroxiredoxins Wear Many Hats:
Factors That Fashion Their Peroxide-Sensing Personalities. Redox Biology. June 2021; 42: 101959.

Bolduc JA., Nelson KJ., Haynes AC., Lee J., Reisz-Haines JA., Graff AH., Clodfelter JE., Parsonage D., Poole
LB., Furdui CM., Lowther WT. Novel Hyperoxidation-Resistance Motifs in 2-Cys Peroxiredoxins. Journal
of Biological Chemistry. June 2018; 293: 11901-11912.

Awards and Accomplishments

Fall 2021	Invited Guest Editor of Antioxidants Special Issue “Redox Language of the Cell”
Summer 2018	Gordon Research Seminar Chair, Thiol-Based Redox Signaling and Regulation