Biological Chemistry/Biophysical/Molecular Biology
Scientific Collaborations of the Wake Forest University Chemistry Department
The Department of Chemistry has a history of Departmental collaborations with, amongst many others, the Wake Forest University School of Medicine (WFUSM). In the past five years, Departmental Instrumentation & Training Grant proposals involving faculty from both Chemistry and Biochemistry have been submitted to the National Institutes of Health, the National Science Foundation, and the North Carolina Biotechnology Center. The most recent examples of these Departmental collaborations are the funded 1995 proposal to NSF for a Triple Quad Mass Spectrometer housed at the School of Medicine, the funded 1997 proposal to the NC Biotechnology Center which assisted in the purchase of new 500 and 300 MHz NMR instruments housed in the Department, and a 1999 NIH training grant with the Department of Cancer Biology. Furthermore, most individual faculty members are involved in collaborative research efforts with School of Medicine faculty and others.
Rebecca Alexander is a member of the Center for Structural Biology and has a cross-appointment to the Department of Cancer Biology. She collaborates with Uli Bierbach to understand the molecular consequences of nucleic acid damage caused by platinum-containing compounds synthesized in the Bierbach lab. Her collaboration with Pamela Jones of Winston-Salem State University is funded by an NIH RIMI (Research Infrastructure at Minority Institutions) grant. This project studies the in vitro activity of E. coli CsdA, a cold-shock protein that destabilizes double-stranded RNA. Dr. Alexander also works with Xianglei Yang of the Scripps Research Institute to determine the high-resolution structure of E. coli methionyl-tRNA synthetase bound to its tRNA substrate.
Ulrich Bierbach is a member of the NCI-designated Comprehensive Cancer Center of Wake Forest University and has a cross-appointment in the Department of Cancer Biology. His collaborators at the Medical School, Sue Hess (Radiation Oncology) and Greg Kucera (Hematology-Oncology) are currently involved in various biological and preclinical studies of the compounds generated in the Bierbach laboratory. The collaborative research efforts include routine in vitro drug screening, radiation sensitization studies, and other experiments addressing the cellular biology of the drug prototypes. Collaborations also exists with the group of Rebecca Alexander in the Chemistry Department and groups abroad (S. J. Berners-Price, University of Western Australia; V. Brabec, National Academy of Sciences of the Czech Republic).
Christa L. Colyer and her research group are involved in numerous research projects with collaborators in other academic institutions, private industry, and other WFU departments. International cooperations provide unique opportunities for the development of intercultural competencies and global competitiveness, involving the Irish Separation Science Cluster http://www.separationscience.
George L. Donati has active collaborations in trace element analysis and analytical instrumentation development with Profs. Clifton Calloway, Jr. (Winthrop University), Joaquim Nóbrega (Federal University of São Carlos, Brazil), José de Anchieta Gomes Neto (Sao Paulo State University, Brazil), Clésia Nascentes (Federal University of Minas Gerais, Brazil), Bradley Jones (WFU), Mirian dos Santos (Sao Paulo State University, Brazil), and Drs. Keith Levine (Research Triangle Institute International) and Daniela Schiavo (Agilent Technologies). Ongoing collaborations in health science related topics involve Profs. Thomas Smith, Cynthia Emory, and Nicole Levi-Polyachenko (WFU School of Medicine), and Prof. Patricia dos Santos (WFU). Ecological and environmental studies are carried out in collaboration with Profs. Todd Anderson (WFU Biology Department) and Bakarr Kanu (Winston-Salem State University).
Willie Hinze has an extensive list of collaborators with whom he participates in a variety of projects. Nationally, Willie collaborates with Professor Stephen Weber (University of Pittsburgh) on micellar chromatography and with Professor Michael Sepaniak (University of Tennessee) on the use of bile salt surfactants in micellar electrokinetic capillary chromatography. Internationally, Dr. Hinze has established collaborations with Professor Frank Quina (University of Sao Paulo, Brazil) on ionene chemistry and applications in chemical analysis; with Edmondo Pramauro (University of Torino, Italy) on surfactant-mediated separation science; with Dr. Isamu Uemasu (National Institute for Resources and Environment, Tsukuba, Japan); and with Dr. Imdad Ullah (University of Peshawar, Pakistan) on the development of new extraction methods and the use of organized assemblies in chemical analysis. Funding for these international ventures has come from various sources, including the NSF, NATO, and Fulbright.
Bradley T. Jones has had several successful collaborations involving trace element analysis of clinical samples provided by researchers at WFUSM. Past collaborations with Dr. Mike Morykwas (WFUSM, Plastic and Reconstructive Surgery), Dr. Fanny Ennever (formerly of WFUSM, Public Health Services), and Dr. Robin Bostic (WFUSM, Public Health Services) have all resulted in joint publications and three funded joint NIH proposals. In addition, Brad has worked with Professor Richard Ehrenkaufer (WFUSM, PET Center) on trace metal analysis of radiopharmaceuticals. Extramural collaborations include work with Dr. Michael Mignardi (Texas Instruments, Dallas, TX) on the use of a digital micromirror device for analytical spectrometry; with Dr. Rick Cone (Perkin Elmer Corporation, Atlanta, GA) on the evaluation of sample preparation equipment for atomic spectrometry; with John Martin (R.J. Reynolds Tobacco Company, Winston-Salem, NC) on trace metal research and collaborative education; and with John R. Leeman (Leeman Labs, Hudson, NH) on the development of instrumentation for trace metal determinations.
S. Bruce King collaborates extensively with Dr. Dany Kim-Shapiro (Physics, WFU). Together, they study the mechanism of action of the drug, hydroxyurea, for the treatment of sickle cell disease and the reaction of nitric oxide and nitrite with both normal and sickle cell hemoglobin in an effort to understand how breathing this gas can provide beneficial effects to sickle cell patients. Recently, they have examined the use of nitric oxide and related compounds to treat hemolytic conditions. Dr. King also works with Dr. Leslie Poole (Department of Biochemistry, WFUSM) on the development of fluorescently and immunologically labeled compounds for the in vivo profiling of protein redox status. Specifically, compounds are synthesized for the detection of protein sulfenic acids, which form through the oxidation of cysteine residues with hydrogen peroxide. Hopefully, these compounds will prove valuable in delineating the role that oxidation plays in many pathophysiological processes including cancinogenesis. Dr. King works with many members of the Comprehensive Cancer Center at Wake Forest, particularly Drs. Karin Scarpinato (Cancer Biology) and Fred Salsbury (Physics) on developing new agents to interact with mis-match repair proteins of DNA as new therapeutics. External to Wake Forest, Dr. King has an active collaboration with Dr. Dave Wink, National Institutes of Health in redox biology and Dr. Nazareno Paolocci, Johns Hopkins University, in identifying new nitric oxide delivery agents for the treatment of congestive heart failure.
Dilip K. Kondepudi has an ongoing collaboration with Kouichi Asakura , Keio University, Japan, on the spontaneous generation and propagation of chiral asymmetry in physical and chemical processes. The collaboration is funded by the Japan Society for the Promotion of Science. In addition, collaborative research is also done with the Robert Compton’s group at the University of Tennessee at Knoxville.
Abdessadek Lachgar has active collaborations with the National High Magnetic Field Laboratory (NHMFL) at Florida State University and Professor Arnold Guloy (University of Houston). This national collaboration focuses on magnetic properties study of materials made in Dr. Lachgar’s laboratory. Our group has set up collaborations and students exchange activities with four different international institutions: University of Mexico (Professor Munoz) funded by NSF; University of Tübingen, Germany (Professor Meyer), The institute of Materials Jean Rouxel, Nantes, France (Professor Piffard and Ouvrard), the university of Nantes (Professor Schleich) and the university of Casablanca, Morocco (Professor ElJazouli) Dr. Lachgar holds an adjunct professorship at the University of Nantes (1999-present), and at the University of Casablanca (1998-present). All our collaborations have strong focus on international student’s development using research as vehicle.
Ronald E. Noftle is currently collaborating with Richard Manderville on the electrochemistry of ochratoxin A and prodigiosins. He and Richard have collaborated on American Cancer Institute and NIH proposals involving these projects. As this research develops, closer associations with the faculty of the Medical School will follow, particularly with those in the Cancer Center. Extramural collaborations include work with Dr. Derek Pletcher (Southampton University, UK) on the electrochemistry of platinum; with Dr. Gary L. Gard (Portland State University) on reactions of thiophenes with fluorinated sulfones; and with Dr. Darryl DesMarteau, (Clemson University) on novel fluorinated imides.
Mark E. Welker has held an appointment as Associate in Biochemistry since 1992, and Associate in Cancer Biology and member of the Comprehensive Cancer Center since 1996. He has contributed to several joint WFUSM/Chemistry proposals and has served as an instructor in Cancer Biology 401. Along with Suzy Torti and Alan Townsend (Biochemistry, WFUSM), he holds a Cross Campus Collaborative Grant for the study of glutathione S-transferase inducers in cell lines. Dr. Welker also collaborates with Bill Rice of Achillion Pharmaceuticals, and David Covell and Andrew Maynard of the NCI Frederick Cancer Center on a project aimed at the synthesis of new anti-HIV-1 compounds that target retroviral nucleocapsid protein zinc fingers.
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